Endocrine Abstracts

Non-alcoholic steatohepatitis (NASH) is a clinical entity characterized by the infiltration of fat into the liver associated with hepatic inflammation. The etiology is unknown, however its most frequently observed in patients with type 2 diabetes mellitus (DM 2), obesity or insulin resistance. DM 2 is an independent risk factor for the progression of NASH. Usually there are no symptoms, so it is not possible to estimate its prevalence. The treatment focuses on the control of a...

Non-alcoholic steatohepatitis (NASH) is a clinical entity characterized by the infiltration of fat into the liver associated with hepatic inflammation. The etiology is unknown, however its most frequently observed in patients with type 2 diabetes mellitus (DM 2), obesity or insulin resistance. DM 2 is an independent risk factor for the progression of NASH. Usually there are no symptoms, so it is not possible to estimate its prevalence. The treatment focuses on the control of a...

Introduction: Cushing’s disease (CD) is a potentially fatal disease caused by corticotrophic adenoma of the pituitary gland. Crooke Cell Adenomas (CCA) are a rare variant characterized by cytoplasmic ring deposits of cytokeratin filaments. They are usually aggressive macroadenomas with a higher rate of recurrence and malignancy.Clinical case: A 36 year old man, with 34 kg weight gain and uncontrolled hypertension for 4 years presented at the Emerge...

Introduction: The prevalence of palpable thyroid nodules in Graves’ disease (GD) is approximately 15%. Cytopathologic interpretation in GD is challenging due to frequent cytomorphologic changes, namely after radioactive iodine (RAI) therapy. Some of the few published studies regarding fine-needle aspiration (FNA) in patients with GD, suggest an increased risk of malignancy of thyroid nodules arising in GD patients. However, the results are inconsistent, and there is no co...

Medullary thyroid carcinoma (MTC) is a rare tumor of C cell origin, that may be sporadic or familial. Diagnosis is often delayed and its course variable.Objectives: Evaluation of clinical characteristics and outcome of patients diagnosed with MTC.Methods: Retrospective analysis of clinical records of patients with MTC between 2005 and 2016. We considered undetectable serum calcitonin as criteria of cure.Resul...

Introduction: In our country somatropin treatment is supported by the National Health Service. A National Committee (CNNHC) rules and analysis the submission papers of patients with: isolated/multiple somatotropin deficiency (STD), short stature in: renal chronic disease (DRC), small for gestational age (SGA), Turner syndrome (TS) and Prader Willi syndrome (PWS). In adults only isolated somatropin deficiency diagnosed in childhood.Aims: To analyze the ch...

Introduction: Treatment with recombinant Somatropin (rSMT) is safe and has greatly improved the approach of children and adolescents with somatropin deficiency (SMTD) and other growth disorders. In our country, rSMT therapy is approved for isolated/multiple somatropin deficiency, small for gestational age (SGA), chronic kidney disease (CKD), Turner syndrome (TS) and Prader Willi syndrome (PWS). A National Commitee (CNNHC) is responsible for the analysis of each case and treatm...